Latest publications
IF = impact factor, ranking; citations [ ]; * shared first authorship; # shared senior authorship; § corresponding authorship (where different to shared senior authorship)
Fyfe I, Pröbstel AK. Anne-Katrin Pröbstel: B cells, antibodies and microbiota in autoimmune disease. Nat Rev Neurol. 2026 May;22(5):268-269. doi: 10.1038/s41582-026-01204-z. PMID: 41963689
Neziraj T, Kappos L, Pröbstel AK. Immunotherapies in progressive multiple sclerosis. Handb Clin Neurol. 2026;214:219-244. doi: 10.1016/B978-0-323-90887-0.00021-3. PMID: 41526136.
Siewert LK*, Berve K*, Pössnecker E, Dyckow J, Zulji A, Baumann R, Munoz-Blazquez A, Krishnamoorthy G, Schreiner D, Sagan S, Nelson C, Sabatino, Jr. JJ, Nagashima K, Diard M, Macpherson AJ, Ganal-Vonarburg SC, Fischbach MA, Zamvil SS, Schirmer L, Sergio E. Baranzini SE #, Pröbstel AK #§. Antigen-specific activation of gut immune cells drives autoimmune neuroinflammation. Gut Microbes. 2026 Dec 31;18(1):2601430. doi: 10.1080/19490976.2025.2601430. Epub 2025 Dec 24. PMID: 41437842. (IF 11, 10/163 in Microbiology, 10/148 in Gasterology & Hepatology) [2]
Wetzel NS*, Kulsvehagen L*, Lecourt AC, Filipek B, Lipps P, Rieder L, Berve K, Krishnamoorthy G, t’ Hart BA, Schirmer L, Yandamuri SS, O’Connor KC#, Pröbstel AK#§. Patient-derived monoclonal myelin oligodendrocyte glycoprotein autoantibodies mediate cytotoxicity. Neurology, Neuroimmunology & Neuroinflammation. 2026 Jan;13(1):e200520. doi: 10.1212/NXI.0000000000200520. Epub 2025 Dec 17. PMID: 41406408. (IF 11.4, 12/212 in Clinical Neurology, 19/275 in Neuro sciences) [5]
Schmid J*, Alberti C*, Power L, Núñez NG, De Feo D, Tyystjärvi S, Kulsvehagen L, Kreiner V, Ayroza Bleher AB, Lipps P, Swinnen S, Ingelfinger F, Ulutekin C, Chaubet C, Unger S, Kreutmair S, Marignier R, Korn K#, Pröbstel AK#, Liblau R#, Becher B#§. Immune signatures link myelin-oligodendrocyte glycoprotein antibody-associated disease to other autoantibody-mediated conditions. Science Translational Medicine. 17, eadw0358(2025). doi:10.1126/scitranslmed.adw0358. Epub 2025 Oct 8. PMID: 41061045 (IF 14.7, 3/195 in Medicine, Research and Experimentation)
Highlighted in:
https://www.immunosensation.de/news/unique-immune-signatures-to-distinguish-mogad-from-ms
van de Burgt NA*, Kulsvehagen L*, Mané-Damas M, Lutz L, Lecourt AC, Monserrat C, Vinke AM, Küçükali CI, Zong S, Hoffmann C, González-Vioque E, Arango C, Leibold NK, Losen M, Molenaar PC, Tüzün E, van Beveren NJM, Mané A, Rouhl RPW, van Amelsvoort TAMJ; for Genetic Risk and Outcome of Psychosis (GROUP) Investigators; Pröbstel AK#, Martinez-Martinez P#. Autoantibodies against myelin oligodendrocyte glycoprotein in a subgroup of patients with psychotic symptoms. Front Neurol. 2025 Jul 18;16:1593042. doi: 10.3389/fneur.2025.1593042. PMID: 40757033; (IF 2.8, 120/285 in Clinical Neurology), 162/314 in Neuro Sciences)
Kim SH*, Gomes* ABAGR, Schindler P, Hyun JW, Kim KH, Lee DE, Schoeps VA, Matos AMB, Mendes NT, Apóstolos-Pereira SLD, Callegaro D, Lerner J, Benkert P, Kuhle J, Ruprecht K, Paul F, Pröbstel AK#, Kim HJ#. Blood-Based Biomarkers for Identifying Disease Activity in AQP4-IgG-Positive Neuromyelitis Optica Spectrum Disorder JAMA Neurol. 2025 Feb 1;82(2):168-175. doi: 10.1001/jamaneurol.2024.4400. PMID: 39714824(IF 20.9, 3/280 in Clinical Neurology) [[16]
Gomes ABAGR*, Kim SH*, Pretzsch R*, Kulsvehagen L, Schaedelin S, Lerner J, Wetzel NS, Benkert P, Maleska Maceski A, Hyun JW, Lecourt AC, Lipps P, Schoeps VA, Matos AMB, Mendes NT, Apóstolos-Pereira SL, Mehling M, Derfuss T, Kappos L, Callegaro D, Kuhle J#, Kim HJ#§, Pröbstel AK#§. Neurofilament Light Chain as a Discriminator of Disease Activity Status in MOG Antibody-Associated Disease. Neurol Neuroimmunol Neuroinflamm. 2025 Jan;12(1):e200347. Epub 2024 Dec 20. doi: 10.1212/NXI.0000000000200347. PMID: 39705633 (IF 11.4, 12/212 in Clinical Neurology, 19/275 in Neuro Sciences) [8]
Key publications
IF = impact factor, ranking; citations [ ]; * shared first authorship; # shared senior authorship; § corresponding authorship (where different to shared senior authorship)
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Wang AA*, Luessi F*, Neziraj T*, Pössnecker E*, Zuo M, Engel S, Hanuscheck N, Florescu A, Bugbee E, Ma XI, Rana F, Lee D, Ward LA, Kuhle J, Himbert J, Schraad M, van Puijenbroek E, Klein C, Ulrich E, Ramaglia V, Pröbstel AK#, Zipp F#, Gommerman JL#. B cell depletion with anti-CD20 promotes neuroprotection in a BAFF-dependent manner in mice and humans. Science Translational Medicine. 2024; 16(737):eadi0295. doi: 10.1001/jamaneurol.2024.4400. PMID: 38446903 (IF15.8, 11/205 in Cell Biology) [31]
Lipps P*, Ayroza Galvão Ribeiro Gomes AB*, Kulsvehagen L*, Mutke MA, Kuhle J, Papadopoulou A, Pröbstel AK. Ongoing Challenges in the Diagnosis of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease. JAMA Neurology. 2023; 80(12):1377-1379. doi: 10.1001/jamaneurol.2023.3956. PMID: 37814961(IF 20.9, 3/280 in Clinical Neurology) [13]
Gomes ABAGR*, Kulsvehagen L*, Lipps P, Cagol A, Cerdá-Fuertes N, Neziraj T, Flammer J, Lerner J, Lecourt AC, Siebenborn NdOS, Cortese R, Schaedelin S, Schoeps VA, Matos AdMB, Mendes NT, Pereira CdR, Monteiro MLR, Pereira SLdA, Schindler P, Chien C, Schwake C, Schneider R, Pakeerathan T, Aktas O, Fischer U, Mehling M, Derfuss T, Kappos L, Ayzenberg I, Ringelstein M, Paul F, Callegaro D, Kuhle J, Papadopoulou A, Granziera C, Pröbstel AK. MOG-IgA characterizes a subgroup of patients with central nervous system demyelination. JAMA Neurology. 2023; 80(9):989-995. doi: 10.1001/jamaneurol.2023.2523. PMID: 37548987(IF 20.9, 3/280 in Clinical Neurology) [38]
Highlighted in:
Editorial correspondence:
Kulsvehagen L, Ayroza Galvão Ribeiro Gomes AB, Pröbstel AK. MOG-IgA as a Potential Marker of Germinal Center Activity-Reply. JAMA Neurol. 2024;81(3):298. doi: 10.1001/jamaneurol.2023.5170. PMID: 38227339
Diebold M*, Meola M*, Purushothaman S*, Siewert LK, Pössnecker E, Roloff T, Lindberg RL, Kuhle J, Kappos L, Derfuss T, Egli A#, Pröbstel AK#§. Gut microbiota composition as a candidate risk factor for dimethylfumarate-induced lymphopenia in multiple sclerosis. Gut microbes. 2022; 14(1):2147055. doi: 10.1080/19490976.2022.2147055. PMID: 36398902(IF 12.2, 9/161 in Microbiology) [25]
Highlighted in:
Kim K*, Pröbstel AK*, Baumann R, Madireddy L, Dyckow J, Loudermilk R, Eggers EL, Singh S, Caillier SJ, Hauser SL, Cree BAC, Schirmer L, Wilson MR, Baranzini SE, UCSF MS-EPIC Team. Targeted transcriptomics identifies neddylation as a novel therapeutic target in multiple sclerosis. Brain. 2021; 144(2):450-461. doi: 10.1093/brain/awaa421. PMID: 33374005(IF 11.3, 5/212 in Clinical Neurology; 10/272 in Neuro Sciences) [41]
Pröbstel AK*§, Zhou X, Baumann R, Rojas OL, Wischnewski S, Kutza M, Sellrie K, Kim K, Ramesh A, Dandekar R, Greenfield AL, Schubert RD, Bisanz JE, Vistnes S, Khalegi K, Liesche-Starnecker F, Ramaglia V, Bischof A, Singh S, Tran EB, Barba P, Heijnen I Oechtering J, Forsberg K, Henry RG, Helmuth J, Shiow LR, Gelfand JM, Graves J, Cree BAC, Hauser SL, Kuhle J, Andersen PM, Schlegel J, Turnbaugh PJ, Seeberger PH, Gommerman JL, Schirmer L, Wilson MR, Baranzini SE*§. Gut-microbiota-specific IgA B cells traffic to the CNS in active multiple sclerosis. Science Immunology. 2020; 5(53):eabc7191. doi: 10.1126/sciimmunol.abc7191. PMID: 33219152(IF 13.4, 5/161 in Immunology) [246]
Highlighted in:
https://www.ucsf.edu/news/2020/11/419086/gut-immune-cells-may-help-send-multiple-sclerosis-remission
https://www.nature.com/articles/d41586-021-01837-8
Rojas OL*, Pröbstel AK*, Porfilio P*, Wang A, Charabati M, Sun T, Lee D, Galicia G, Ramaglia V, Ward LA, Leung LYT, Najafi G, Khalegi K, Chiaranunt P, Garcillan B, Li A, Besla R, Naouar I, Cao EY, Yam J, Luck H, Campbell DJ, Allman D, Brooks DG, Tomura M, Baumann R, Zamvil SS, Bar-Or A, Horwitz MS, Winer DA, Mortha A, Mackay F, Prat A, Osborne L, Robbins C, Baranzini SE, Gommerman JL. Recirculating Intestinal IgA-producing cells Regulate Neuroinflammation via IL10. Cell. 2019; 176(3):610-624. doi: 10.1016/j.cell.2018.11.035. PMID: 30612739(IF 31.4, 2/285 in Biochemistry & Molecular Biology) [482]
Highlighted in:
https://www.ucsf.edu/news/2019/01/412941/gut-immune-cells-cut-inflammation-multiple-sclerosis
Pröbstel AK, Kuhle J, Lecourt AC, Vock I, Sanderson NSR, Kappos L, Derfuss T. Multiple Sclerosis and Antibodies against KIR4.1. NEJM. 2016; 374(15):1496-8. doi: 10.1056/NEJMc1507131. PMID: 27074084(IF 72.4, 2/167 in Medicine) [25]
Pröbstel AK, Rudolf G, Dornmair K, Collongues N, Chanson JB, Sanderson NSR, Lindberg RLP, Kappos L, de Seze J*, Derfuss T*. Anti-MOG antibodies are present in a subgroup of patients with a neuromyelitis optica phenotype. J Neuroinflamm, 2015; 12(1):46. doi: 10.1186/s12974-015-0256-1. PMID: 25889963 (IF 4.7, 24/151 in Immunology, 50/256 in Neuro Sciences) [212]
Pröbstel AK, Dornmair K, Bittner R, Sperl P, Jenne D, Magalhaes S, Villalobos A, Breithaupt C, Weissert R, Jacob U, Krumbholz M, Kuempfel T, Blaschek A, Stark W, Gärtner J, Pohl D, Rostasy K, Weber F, Forne I, Khademi M, Olsson T, Brilot F, Tantsis E, Russell D, Wekerle H, Hohlfeld R, Banwell B#, Bar-Or A#, Meinl E#§, Derfuss T#. Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis. Neurology, 2011; 77(6):580-8. doi: 10.1212/WNL.0b013e318228c0b.PMID: 21795651(IF 8.3, 12/212 in Clinical Neurology) [371]